for the layman: CML (Carboxymethyllysine) is a chemical modification of lysine residues on proteins. It

40%) DR, can reproduce these effects in mitochondria from vital tissues of strong relevance for aging

also generates massive lactate. Moreover, senescent microglia-trigged accumulation of lactate caused enhanced histone lysine lactylation (Kla) levels, contributing

by complex I under the phosphorylative state (state 3) , we observed a strong reduction in oxygen

able to measure biological age from a tissue sample is a strong incentive, as this capability